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Cake day: July 11th, 2023

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  • You don’t need personal genomics to broadly do better than simply lumping everyone in one bucket. Various ethnic/racial groups have been mostly reproductively isolated from each other for most of history, which means certain things are significantly more common in some groups than others, which means you can get more effective use of resources by targeting things like screening and prevention at groups where the disease is more likely.

    Personal genomics would let you target even more closely, but using race or family history is just estimating genomics by proxy.

    For example, sickle cell and black folks, or cystic fibrosis and white folks, or maple syrup urine disease and the Amish or methemoglobinemia and one family from eastern Kentucky.



  • This is pretty disingenuous, the vast majority of sickle cell cases are non-hispanic blacks. Hispanics and whites also get sickle cell. If you’re grouping all those ethnicities in there, you might as well include whites too.

    It’s genetic. It’s more prevalent in some populations than others because sickle cell also makes one resistant to malaria, so the more common malaria has been somewhere historically, the more likely people descended from there are to have sickle cell.

    Like how people of European descent are more likely to be resistant to the Black Death. Turns out diseases that kill lots of people apply significant selection pressure and those changes don’t vanish quickly unless they cause a problem that would prevent breeding in successive generations.