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That depends, the Fallout and Elder Scrolls games are easily modded regardless of OS, and I’ve had good luck with HedgeModManager too for Sonic Generations, and even for Civ3, C3X fixes the black map bug however I haven’t found a good fix for the crackling and popping audio.

I’m more of a proponent for running some Linux distro for my main OS and then virtualizing Windows if desired for things that are broken in WINE/Proton somehow but work fine in Windows, at this point.

I don’t trust Windows enough to run it baremetal in a dual-boot anymore though, virtualization at least isolates it from the host where it counts, where in a dual-boot, even if it generally doesn’t happen, there’s still the looming threat of Windows screwing up the Linux install somehow, where that isn’t a problem when virtualizing since, as I said, it’s isolated where it counts, even if paravirtualization is a thing for storage drivers and networking and the like, and hardware passthrough is a thing for things like GPUs.

There’s still the odd game that’s somehow broken in WINE that isn’t broken by anticheat or DRM, but by just being crusty code, but those edge cases will do fine in a Windows VM /w a spare GPU being passed through to it.

Anything that uses kernel anticheat, so basically any modern multiplayer title, is platform-locked into a baremetal Windows install, but since I have no interest whatsoever in modern multiplayer titles and thus no interest in anything with a kernel anticheat, I can do just fine virtualizing Windows in that scenario while using a Linux host for everything else.

(which, Soulbringer, one of my previous edge-case titles, works great in Proton /w dxwrapper+DXVK, but Civ3’s audio is still broken in Proton even if C3X fixes the graphics, so that’s still being ran in a Windows VM, which I currently have Win11 LTSC running in a VM /w my Vega 56 being passed through to it for just that very purpose, while I’m using an RX 6600 for my host card)

As for apps like Maya, Blender is actually competitive with it nowadays.

As an addendum relating to modern multiplayer titles, those are the few titles where it would make more sense to play them on console instead of PC anyways since the way in which they’re locked down goes against PC’s main selling point: the fact that you actually own your system to a degree where the consoles are effectively locked into the PS, Xbox, or Nintendo walled garden.